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[news 2003-2004]




Queen's, McGill University spinoff companies and NeuroSearch of Denmark join forces to address chronic pain

PainCeptor Pharma Corp's novel technologies for pain management therapy attract $23 million in initial investment


March 23, 2004

KINGSTON, ON – Neuroceptor, Inc., and Antalium Inc., spinoff companies of Queen's University and McGill University respectively, are pleased to announce their merger into a new company, PainCeptor Pharma Corporation. The company will operate from facilities in Montreal, Quebec and Kingston, Ontario.

The alliance capitalizes on the two companies' complementary research into the signalling molecules that regulate the sensory transmission of chronic pain. PainCeptor will also acquire key complementary technology from NeuroSearch A/S, a European pharmaceutical company and strategic partner of Antalium.

The new biopharmaceutical company will focus on developing novel drugs for the treatment of peripheral pain. Peripheral pain occurs outside the central nervous system and is associated with conditions such as tissue injury and chronic inflammatory diseases such as arthritis. Clinical trials of the company's lead compound are expected to begin in 2005.

PainCeptor is financed with investment funding of $23 million, which will be used to advance the company's lead compounds into clinical trials. The financing is led by CDP Capital – Technology Ventures, with additional investment from the Business Development Bank of Canada, Desjardins Venture Capital, Canadian Medical Discoveries Fund Inc., T2C2/BIO 2000, MDS Capital Corporation and Innovatech du Grand Montréal.

Chronic pain afflicts millions of individuals worldwide in a variety of diseases and conditions, including cancer, arthritis, fibromyalgia, and tissue injury. The therapeutic market for chronic pain control is extensive and remains largely unmet. Existing treatments for chronic pain are few, and current drugs, which include morphine and other opioid-like medications, can cause serious side effects and addiction.

Leading the new company is Dr. Louis Lamontagne, the former president and CEO of the Montreal-based pharmaceutical company Neurochem Inc. "We are excited by this new opportunity," says Dr. Lamontagne. "Antalium and Neuroceptor, under the stewardship of Mr. Kazimierz Babinski and Dr. Greg Ross respectively, have achieved remarkable progress in the science of pain control. They have identified preliminary leads, established proof of principle in certain well recognized pain pharmaceutical models, and developed a strong patent position -- all this on modest financial resources. By targeting specific molecules within the peripheral nervous system, where the initial, crucial steps of the pain cascade occur, our novel compounds offer new hope for the development of highly efficacious and safe pain medication."

"PainCeptor's innovative technologies offer great potential in an area of need that is largely unmet," says John Molloy, President and CEO of PARTEQ Innovations, a founder of Neuroceptor. "The combination of unique and complementary technologies developed by these two companies offers tremendous potential in the treatment of chronic pain and other peripheral nervous system disorders."

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Contact:
Dr. Louis Lamontagne
President and CEO
PainCeptor Pharma Corp.
613. 748. 0990
llamontagne@painceptor.com
www.painceptor.com

John Molloy
President & CEO,
PARTEQ Innovations
613. 533. 2342
jmolloy@parteqinnovations.com
www.parteqinnovations.com


About Neuroceptor Inc.
Neuroceptor Inc. was founded in 1998 by PARTEQ Innovations and Drs. Gregory Ross and Richard Riopelle of Queen's University. Their research into nerve-cell receptor modulators called neurotrophins resulted in the development of novel molecules for modulating the processes that cause pain. Neuroceptor received $500,000 in investment R&D funding from University Medical Discoveries Inc. and the Working Ventures CMDF Queen's Scientific Breakthrough Fund.

About Antalium Inc.
Antalium Inc. was founded in 1999 by Mr. Kazimierz Babinski, Astra Research Fellow, and Dr. Philippe Seguela, both of McGill University, on patented technologies in the field of sensory neuron ion channels discovered at the Montreal Neurological Institute of McGill University. McGill University's Office of Technology Transfer launched the company, generating $3 million in investment from T2C2/BIO Limited Partnership and MedTech Partners.

About Neurosearch A/S
NeuroSearch is a Danish biopharmaceutical company focused on unmet medical needs to address diseases of the central nervous system and other disorders. A Copenhagen Stock Exchange-listed company (NEUS:CO), Neurosearch has a broad research and development portfolio that includes compounds for the treatment of ADHD, Alzheimer's, cancer, epilepsy, brain damage after stroke, pain and Parkinson's disease.

About PainCeptor Pharma Corp.
PainCeptor Pharma Corporation is a Canadian-based, private biopharmaceutical company focused on drug development for the treatment of acute and chronic pain. The company has lead compounds active at several sites in the peripheral nervous system and will begin clinical trials for these programs in 2005. The company's intellectual property portfolio includes 33 issued patents and 43 active filings.



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